Why the study?
Does treatment with beta-adrenoceptor antagonists in vivo alter human adenylate cyclase responsiveness in vitro in healthy volunteers?
Population
Healthy volunteers
Comparison
Beta-adrenoceptor antagonists in vivo for a… vs Baseline and 7 days after drug withdrawal
Design
Other
Follow-up
14 days (7 days treatment, 7 days withdrawal)
Authors
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Circulating blood cell adenylate cyclase may not reflect cardiac responses to beta-blockers; leaves open direct myocardial assessment in patients.
Does treatment with beta-adrenoceptor antagonists in vivo alter human adenylate cyclase responsiveness in vitro in healthy volunteers?
Adenylate cyclase responsiveness in circulating blood cells does not reflect alterations in solid tissues like the human heart following beta-blocker treatment.
Michel et al. (1991) studied this question.
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