Predictors of Spontaneous Reverse Remodeling in Mild Heart Failure Patients With Left Ventricular Dysfunction
Why the study?
What are the predictors of spontaneous left ventricular reverse remodeling in mild heart failure patients with left ventricular dysfunction, and how do they impact clinical outcomes?
Population
714 mildly symptomatic heart failure patients with left ventricular dysfunction treated with internal…
Design
Cohort
Follow-up
1-year
Authors
Discussion
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Member takes
Implication
May help select mild HF patients for ICD-only management; hypothesis-generating for score-based CRT decisions pending trials.
Structured PICO
What are the predictors of spontaneous left ventricular reverse remodeling in mild heart failure patients with left ventricular dysfunction, and how do they impact clinical outcomes?
P
Population
714 mildly symptomatic heart failure patients with left ventricular dysfunction treated with internal cardioverter defibrillator (ICD)-only therapy in the MADIT-CRT trial.
I
Intervention
Clinical factors associated with spontaneous left ventricular reverse remodeling (S-LVRR) and a derived S-LVRR score.
O
Outcome
Spontaneous left ventricular reverse remodeling (S-LVRR), defined as ≥15% reduction in left ventricular end-systolic volume at 1-year of follow-up, and a composite of heart failure or death.composite
Approximately 25% of mild HF patients eligible for biventricular pacing experience spontaneous reverse remodeling, and a clinical score can identify those at low risk for clinical events without CRT intervention.
Cite This Study
Brenyo et al. (2014) studied this question.