August 1, 1998Annals of MedicineOpen Access

From overload to failure: what happens inside the myocyte

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Population

Individual myocytes isolated from normal and failing human myocardium

Design

Review

Authors

SHSiân E. HardingHeart Failure & Transplant KDKerry DaviaImperial College London CDCrispin H. DaviesOregon Health & Science University

Discussion

Member takes

Implication

Supports myocyte-level basis for HF contractile defects; leaves open translation to targeted therapies pending prospective validation.

Structured PICO

Population

Individual myocytes isolated from normal and failing human myocardium

Comparator

Myocytes from normal human myocardium

Outcome

Myocyte contraction and relaxation kinetics, contraction amplitude, beta-adrenoceptor desensitization, and action potential durationsurrogate

Functional defects in the failing human heart, such as slowed relaxation and beta-adrenoceptor desensitization, are intrinsically present at the level of the isolated single myocyte.

Cite This Study

Harding et al. (1998) studied this question.

synapsesocial.com/papers/6a6f6fa7febe604dd7085aaf https://doi.org/10.1080/13652060.1998.12527711

Topics

Hypertrophic cardiomyopathy Heart failure HFrEF treatment

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From overload to failure: what happens inside the myocyte

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

From overload to failure: what happens inside the myocyte

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider