August 1, 2002Anesthesia & Analgesia

Intravenous Verapamil Blunts Hyperdynamic Responses During Electroconvulsive Therapy Without Altering Seizure Activity

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Why the study?

Does IV verapamil blunt the acute hyperdynamic responses (heart rate and blood pressure) without altering seizure duration in patients undergoing electroconvulsive therapy?

Population

16 ASA physical status I, II, or III patients undergoing ECT treatments for chronic depression. Mean age 52…

Comparison

Verapamil 0.1 mg/kg IV administered at a rate of… vs Matching placebo administered at a rate of 2.4 ×…

Design

RCT, randomized crossover study design, double-blinded, placebo-controlled

Follow-up

Acute post-ECT period

Authors

ZWZen’ichiro WajimaSaitama Medical University Hospital TYTatsusuke YoshikawaJikei University School of Medicine AOAkira OguraTeikyo University

Discussion

Member takes

Implication

Supports verapamil pretreatment to blunt hemodynamic surges in ECT; confirms preserved seizure duration in this RCT.

Structured PICO

Does IV verapamil blunt the acute hyperdynamic responses (heart rate and blood pressure) without altering seizure duration in patients undergoing electroconvulsive therapy?

Population

16 ASA physical status I, II, or III patients undergoing ECT treatments for chronic depression (32 ECT treatments total). Mean age 52, 31% male (5 men, 11 women). Key exclusions: unstable cardiovascular diseases, receiving beta-adrenergic or other calcium channel-blocking drugs, second- or third-degree AV block, arrhythmia, hypotension, sinus bradycardia, COPD, and renal or hepatic failure.

Intervention

Verapamil 0.1 mg/kg IV (0.025% solution) administered at a rate of 2.4 × body weight mL/h for a 10-minute period immediately before anesthesia induction for ECT.

Comparator

Matching placebo (normal saline) administered at a rate of 2.4 × body weight mL/h for a 10-minute period immediately before anesthesia induction for ECT.

Outcome

Effect of IV verapamil administration on heart rate (HR), arterial blood pressure, and seizure duration (motor and EEG) during ECT.surrogate

Intravenous verapamil effectively blunts the acute hyperdynamic cardiovascular responses to electroconvulsive therapy without compromising the duration of the therapeutic seizure.

Cite This Study

Wajima et al. (2002) studied this question.

synapsesocial.com/papers/6a6f82d9ac440176ef282fd9 https://doi.org/10.1213/00000539-200208000-00030

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Intravenous Verapamil Blunts Hyperdynamic Responses During Electroconvulsive Therapy Without Altering Seizure Activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intravenous Verapamil Blunts Hyperdynamic Responses During Electroconvulsive Therapy Without Altering Seizure Activity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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