Population
24 3- to 6-day-old gnotobiotic (Gn) pigs
Comparison
Inoculation with tissue culture-adapted Cowden… vs Mock inoculation with serum-free EMEM or…
Design
Preclinical, Histologic evaluation was done in a blind fashion on coded samples
Follow-up
Up to 28 days post-inoculation
Authors
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TC-adapted PEC attenuation in pigs may guide calicivirus vaccine strategies; leaves open human relevance given preclinical model.
The study demonstrates that tissue culture-adapted porcine enteric calicivirus is attenuated in gnotobiotic pigs, and that intravenous inoculation of wild-type virus induces diarrhea and intestinal lesions, confirming the occurrence of viremia.
Guo et al. (2001) studied this question.
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