June 1, 1988American Journal of Veterinary Research
Pathogenesis of porcine enteric calicivirus-like virus in four-day-old gnotobiotic pigs
Why the study?
Does oral inoculation with porcine enteric calicivirus-like virus cause intestinal lesions and diarrhea in 4-day-old gnotobiotic pigs?
Population
25 4-day-old gnotobiotic pigs (18 inoculated, 7 controls)
Comparison
Oral inoculation with porcine enteric… vs Noninoculated controls
Design
Preclinical
Follow-up
7 days
Authors
Discussion
Loading...
Member takes
Implication
Establishes gnotobiotic pig model for calicivirus enteritis; leaves open applicability to natural infections in commercial herds.
Structured PICO
Does oral inoculation with porcine enteric calicivirus-like virus cause intestinal lesions and diarrhea in 4-day-old gnotobiotic pigs?
P
Population
25 4-day-old gnotobiotic pigs (18 inoculated, 7 controls)
I
Intervention
Oral inoculation with porcine enteric calicivirus-like virus (C strain)
C
Comparator
Noninoculated controls
O
Outcome
Development of diarrhea, immunofluorescence in villous epithelial cells, and villus length/atrophysurrogate
Oral inoculation of porcine enteric calicivirus-like virus in gnotobiotic pigs causes diarrhea and significant villus atrophy in the small intestine.
Cite This Study
Flynn et al. (1988) studied this question.