Key result
Inoculation of gnotobiotic pigs with US PEDV strain PC21A resulted in severe watery diarrhea, vomiting, fecal shedding, viremia, and severe atrophic enteritis within 24-48 hours.
Absolute Event Rate: 100% vs 0%
The newly emerged US PEDV strain PC21A is highly enteropathogenic, causing severe atrophic enteritis and viremia in a gnotobiotic pig model.
Confirms high enteropathogenicity of US PEDV PC21A in gnotobiotic pigs; leaves open translation to commercial herds and control measures.
To understand the progression of porcine epidemic diarrhea virus infection, we inoculated gnotobiotic pigs with a newly emerged US strain, PC21A, of the virus. At 24–48 hours postinoculation, the pigs exhibited severe diarrhea and vomiting, fecal shedding, viremia, and severe atrophic enteritis. These findings confirm that strain PC21A is highly enteropathogenic.
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Jung et al. (2014) studied Porcine Epidemic Diarrhea Virus (PEDV) infection (n=6). US PEDV strain PC21A vs. Negative control was evaluated on Development of clinical signs (diarrhea, vomiting), fecal shedding, viremia, and atrophic enteritis. Inoculation of gnotobiotic pigs with US PEDV strain PC21A resulted in severe watery diarrhea, vomiting, fecal shedding, viremia, and severe atrophic enteritis within 24-48 hours.
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