Why the study?
Does losartan improve insulin sensitivity, lipid profile, and endothelin in normotensive offspring of hypertensive parents?
Population
19 young, healthy, lean normotensive male offspring of essential hypertensive parents
Comparison
Losartan 50 mg daily for 14 days vs Placebo for 14 days
Design
RCT, Randomized crossover design, Double-blind
Follow-up
14 days per phase
Authors
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Losartan does not improve insulin sensitivity or ET-1 in this population; confirms modest lipid reductions independent of blood pressure.
Does losartan improve insulin sensitivity, lipid profile, and endothelin in normotensive offspring of hypertensive parents?
In normotensive offspring of hypertensive parents, short-term treatment with losartan 50 mg daily did not affect insulin sensitivity or endothelin-1 but significantly reduced total cholesterol and triglycerides.
Lerch et al. (1998) studied this question.
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