Population
Rats (isolated cardiac sarcoplasmic reticulum)
Design
Preclinical
Follow-up
6 weeks
Authors
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Hypothyroidism-linked SR calcium deficits in rats should not change practice; leaves open translational role in human cardiomyopathy.
Hypothyroidism reduces cardiac sarcoplasmic reticulum calcium transport activity in rats, likely due to a reduction in the quantity of SR calcium pump sites.
Black et al. (2008) studied this question.
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