Why the study?
Does the pericardium alter the left ventricular diastolic pressure-segment length relation during cardiac distension and afterload reduction in conscious dogs?
Population
7 conscious chronically instrumented dogs
Comparison
Pericardiectomy with acute volume loading and… vs Same dogs with intact pericardium under control…
Design
Preclinical
Follow-up
3-9 days after pericardiectomy
Authors
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Pericardial constraint may drive diastolic pressure elevations during acute dilatation; leaves open translation to human LV compliance assessment.
Does the pericardium alter the left ventricular diastolic pressure-segment length relation during cardiac distension and afterload reduction in conscious dogs?
The pericardium significantly contributes to increased left ventricular diastolic pressure during acute cardiac dilatation and is responsible for shifts in the diastolic pressure-segment length relation.
Shirato et al. (1978) studied this question.
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