Population
Avian sarcoma virus system
Comparison
Analysis of splicing mutations vs Wild-type or unmutated viral RNA
Design
Preclinical
Authors
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Hypothesis-generating in animal retroviral models; leaves open whether cis-signal targeting offers antiviral strategies in humans.
Retroviral RNA splicing is regulated by suboptimal cis-acting signals to maintain a balance between full-length genomic RNA and subgenomic mRNAs.
Katz et al. (1990) studied this question.
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