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February 1, 1990Molecular and Cellular Biology

Control of retroviral RNA splicing through maintenance of suboptimal processing signals.

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Population

Avian sarcoma virus system

Design

Preclinical

Authors

RKRichard A. KatzFox Chase Cancer CenterASA M SkalkaUtah State University

Discussion

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Implication

No immediate clinical implications from this animal study; leaves open therapeutic targeting of retroviral splicing signals in humans.

Structured PICO

P
Population
Avian sarcoma virus system
I
Intervention
Mutations in the viral RNA (specifically around the env splice acceptor site)
O
Outcome
Splicing efficiency and viral replicationsurrogate

Retroviral RNA splicing is regulated by suboptimal cis-acting signals to maintain a balance between full-length and subgenomic transcripts.

Cite This Study

Katz et al. (1990) studied this question.

synapsesocial.com/papers/6a6f9a67c92390ac2d07a467https://doi.org/10.1128/mcb.10.2.696
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A conserved cis-acting sequence in the 5' leader of avian sarcoma virus RNA is required for packaging1986 · 120 citations
  2. 2Multiple regions in the Rous sarcoma virus src gene intron act in cis to affect the accumulation of unspliced RNA1989 · 76 citations
  3. 3A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication1988 · 28 citations
  4. 4Transforming viruses spontaneously arise from nontransforming reticuloendotheliosis virus strain T-derived viruses as a result of increased accumulation of spliced viral RNA1988 · 14 citations
  5. 5Inhibition of splicing but not cleavage at the 5' splice site by truncating human beta-globin pre-mRNA.1986 · 58 citations