What question did this study set out to answer?

Quantify plasma concentrations of the fast inhibitor of tissue plasminogen activator throughout healthy pregnancy and assess variations in high-risk pregnancies.

January 1, 1984Thrombosis and Haemostasis

The Fast Inhibitor of Tissue Plasminogen Activator in Plasma During Pregnancy

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Authors

BWB. WimanKarolinska University Hospital GCG. CsemiczkyKarolinska University Hospital LML. MarskKarolinska University Hospital

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Implication

Observational study reveals progressive increases in tissue plasminogen activator inhibitor during pregnancy with wide deviations in high-risk cases, suggesting altered fibrinolytic regulation.

Key Points

Quantify plasma concentrations of the fast inhibitor of tissue plasminogen activator throughout healthy pregnancy and assess variations in high-risk pregnancies.
Measured plasma levels of the fast inhibitor of tissue plasminogen activator across 20 healthy non-pregnant women, 48 healthy pregnant women, and 136 women with risk pregnancies.
Included high-risk pregnancies characterized by preeclampsia, suspected fetal growth retardation, diabetes, or a history of thrombosis.
In healthy non-pregnant women, inhibitor levels were 0.4 +/- 0.7 U/ml, remaining stable until gestational week 10 before linearly increasing to approximately 6.5 U/ml by week 40.
Third-trimester inhibitor concentrations spanned 4.0 to 6.4 U/ml in healthy pregnant controls, compared to a widely dispersed range of 0 to 24.0 U/ml in high-risk pregnancies.

Cite This Study

Wiman et al. (1984) studied this question.

synapsesocial.com/papers/6a6fa3c5e5469ee92be086b1 https://doi.org/10.1055/s-0038-1661154

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Implication

Observational study reveals progressive increases in tissue plasminogen activator inhibitor during pregnancy with wide deviations in high-risk cases, suggesting altered fibrinolytic regulation.

The Fast Inhibitor of Tissue Plasminogen Activator in Plasma During Pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

The Fast Inhibitor of Tissue Plasminogen Activator in Plasma During Pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

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