Why the study?
Although physiological changes in hemostasis during pregnancy have been reported, reference intervals for specific hemostasis biomarkers in healthy pregnancies needed to be established.
Population
496 healthy pregnant women and 103 healthy nonpregnant women
Comparison
Trimester-specific and pre-labor pregnancy stages vs nonpregnant women
Key result
Trimester-specific reference intervals for hemostasis biomarkers were established in healthy pregnancies, with TAT showing increasing concentrations throughout pregnancy.
Authors
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May guide hemostasis marker interpretation in pregnancy; leaves open need for outcome validation before clinical adoption.
Cross-Sectional (n=599)
No
This study provides trimester-specific reference intervals for hemostasis biomarkers in healthy pregnancies, highlighting that TAT levels increase significantly throughout gestation.
Haijun et al. (2023) conducted a cross-sectional in Healthy pregnancy (n=599). Pregnancy vs. Non-pregnant women was evaluated on Trimester-specific reference intervals for hemostasis biomarkers (TAT, PIC, TM, tPAI-C). Trimester-specific reference intervals for hemostasis biomarkers were established in healthy pregnancies, with TAT showing increasing concentrations throughout pregnancy.
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