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Coagulation parameters change significantly with advancing gestational age, requiring distinct, trimester-specific reference intervals for pregnant women to accurately recognize abnormalities. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 19, 2026BMC Pregnancy and ChildbirthOpen Access

Establishing trimester-specific reference intervals for coagulation parameters in pregnant women in China

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Authors

LZLong ZhangWomen's Hospital, School of Medicine, Zhejiang University YSYifang ShenWomen's Hospital, School of Medicine, Zhejiang University KWKaiqi WuMax Planck Institute for Polymer Research

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Implication

Randomized trial establishes trimester-specific coagulation reference intervals in pregnant women, suggesting improved clinical decision-making.

Key Points

The study aims to establish accurate reference intervals for coagulation parameters in pregnant and non-pregnant women in China.
Analyzed blood samples from 879 pregnant women and 253 healthy non-pregnant women between January 2023 and February 2024.
Tested parameters included APTT, PT, TT, fibrinogen, D-dimer, FDP, PLG, TAT, TM, PIC, and t-PAIC.
Established reference intervals using a non-parametric method.
PT, INR, APTT, and TT values decreased with pregnancy, while fibrinogen, D-dimer, FDP, PLG, TM, TAT, PIC, and t-PAIC levels increased significantly.
Distinct reference intervals established for non-pregnant women and women in first, second, and third trimesters.
Most intervals showed significant differences across non-pregnant and pregnant groups.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a0bfe08166b51b53d37946f https://doi.org/10.1186/s12884-026-09296-7

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May 19, 2026BMC Pregnancy and ChildbirthOpen Access

Establishing trimester-specific reference intervals for coagulation parameters in pregnant women in China

View Full Paper

Ask AI

Bookmark

Authors

LZLong ZhangWomen's Hospital, School of Medicine, Zhejiang University YSYifang ShenWomen's Hospital, School of Medicine, Zhejiang University KWKaiqi WuMax Planck Institute for Polymer Research

Discussion

Member takes

Implication

Randomized trial establishes trimester-specific coagulation reference intervals in pregnant women, suggesting improved clinical decision-making.

Key Points

The study aims to establish accurate reference intervals for coagulation parameters in pregnant and non-pregnant women in China.
Analyzed blood samples from 879 pregnant women and 253 healthy non-pregnant women between January 2023 and February 2024.
Tested parameters included APTT, PT, TT, fibrinogen, D-dimer, FDP, PLG, TAT, TM, PIC, and t-PAIC.
Established reference intervals using a non-parametric method.
PT, INR, APTT, and TT values decreased with pregnancy, while fibrinogen, D-dimer, FDP, PLG, TM, TAT, PIC, and t-PAIC levels increased significantly.
Distinct reference intervals established for non-pregnant women and women in first, second, and third trimesters.
Most intervals showed significant differences across non-pregnant and pregnant groups.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a0bfe08166b51b53d37946f https://doi.org/10.1186/s12884-026-09296-7

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