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This study aimed to investigate changes in coagulation biomarkers during pregnancy and establish trimester-specific reference intervals.

July 11, 2026Scientific ReportsOpen Access

Trimester-specific reference intervals for coagulation biomarkers (TAT, PIC, TM, tPAI-C) and their clinical associations in healthy Chinese pregnant women

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Randomized trial explores coagulation biomarkers in healthy pregnant women, indicating significant associations with BMI and blood pressure.

This study aimed to investigate changes in coagulation biomarkers during pregnancy and establish trimester-specific reference intervals.
Enrolled 329 healthy pregnant women undergoing prenatal care from November 2024 to June 2025.
Quantified biomarker levels using automated fluorescence immunoassays.
Established reference intervals based on CLSI EP28-A3c guidelines.
TAT, TM, and tPAI-C increased across trimesters, while PIC decreased.
Gestational week significantly influenced all biomarkers.
Current BMI negatively influenced TAT, while diastolic blood pressure positively influenced tPAI-C.

Ji et al. (2026) studied this question.

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Randomized trial explores coagulation biomarkers in healthy pregnant women, indicating significant associations with BMI and blood pressure.