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June 20, 2026BMC Pregnancy and ChildbirthOpen Access

Establishment of biological reference intervals for coagulation indicators in pregnancy using a non-parametric approach

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Authors

XLX J LiBMBangzhu MoCXChunbao Xie

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Overview

Randomized trial evaluates trimester-specific coagulation indicators in healthy pregnant women, suggesting new clinical reference intervals.

Key Points

  • The aim is to establish trimester-specific reference intervals for coagulation indicators in healthy pregnant women.
  • Evaluated APTT, PT, TT, FIB, and DD levels in 2,657 healthy pregnant women across three trimesters.
  • Used the non-parametric percentile method according to CLSI C28-A3 guidelines.
  • Included a control group of 198 healthy non-pregnant women for comparison.
  • Significant differences found in APTT, PT, and TT levels across trimesters (P < 0.01), with decreases observed.
  • FIB and DD levels increased significantly with gestational age across trimesters (P < 0.01).
  • Established reference intervals for coagulation indicators validated in an independent sample of 20 women per trimester.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a3632fcdb0793dc1a53970chttps://doi.org/10.1186/s12884-026-09504-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Establishing trimester-specific reference intervals for coagulation parameters in pregnant women in China2026
  2. 2Establishment Trimester-Specific Reference Intervals of Anticoagulation and Fibrinolysis Indicators in Healthy Pregnant Women in Beijing, China2025
  3. 3Trimester-specific reference intervals for coagulation biomarkers (TAT, PIC, TM, tPAI-C) and their clinical associations in healthy Chinese pregnant women2026
  4. 4Trimester-specific reference intervals of hemostasis biomarkers for healthy pregnancy2023 · 3 citations
  5. 5Reference Values of D‐Dimers and Fibrinogen in the Course of Physiological Pregnancy: the Potential Impact of Selected Risk Factors—A Pilot Study2020 · 47 citations