Key result
Pregnancy alters 13 anticoagulant and fibrinolytic indicators, requiring trimester-specific reference intervals.
Why the study?
To track changes in anticoagulation and fibrinolysis indicators across different pregnancy periods and establish trimester-specific reference intervals in healthy pregnant women.
Observational (n=200)
No
This study establishes trimester-specific reference intervals for 13 anticoagulant and fibrinolytic indicators in healthy pregnant women in Beijing, China, highlighting the need for pregnancy-specific reference ranges.
Answers are grounded in this paper and cite their sources.
Supports trimester-specific coagulation reference intervals in pregnancy; leaves open whether adoption improves maternal outcomes.
ObjectiveContinuously tracking and monitoring the changes in indicators of anticoagulation and fibrinolysis in healthy pregnant women during different pregnancy periods, to establish trimester-specific reference intervals.MethodsA total of 200 healthy pregnant women registered in Peking University First Hospital were enrolled. Venous blood samples were collected at different pregnancy periods, and thirteen related anticoagulation and fibrinolysis indicators were tested. The impact of pregnancy periods on these indicators were analyzed, and corresponding reference intervals were established.ResultsSignificant differences were observed among the non-pregnant group and the first trimester(6-8weeks), second trimester(24-28weeks), and third trimester(36-38weeks) groups for antithrombin (AT), protein S activity (PS Ac), free protein S (FPS), protein C (PC), D-Dimer, fibrin/fibrinogen degradation products (FDP), plasmin inhibitor (PI), plasminogen (PLG), von Willebrand factor activity (vWF:Ac), von Willebrand factor antigen (vWF:Ag), lupus anticoagulant. AT, PS Ac, and FPS showed a downward trend with increasing gestational period. PI was significantly increased in the first trimester. PLG and vWF:Ag was higher in the second trimester and the third trimester. vWF:Ac, D-Dimer and FDP showed an continuously upward trend with increasing gestational period; the normalized SCT ratio (SCT TR)was significantly lower in the third trimester; the normalized dRVVT ratio (dRVVT TR)was significantly higher in the second and third trimester.ConclusionThis study established reference intervals for thirteen anticoagulant and fibrinolytic indicators in healthy pregnant women in Beijing, China. Additionally, pregnancy periods affect the test results of anticoagulant and fibrinolytic indicators in pregnant women, and the reference intervals should be established separately according to pregnancy periods.
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Miao et al. (2025) conducted an observational in Healthy pregnancy (n=200). Pregnancy vs. Non-pregnant women was evaluated on Anticoagulation and fibrinolysis indicators. Pregnancy significantly altered thirteen anticoagulant and fibrinolytic indicators across trimesters compared to non-pregnant women, necessitating trimester-specific reference intervals.
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