Why the study?
Does slow pressor angiotensin II infusion induce cerebrovascular dysfunction before the development of hypertension in mice?
Population
Male C57BL/6J mice (age 2 to 3 months, 20-30 g body weight)
Comparison
Angiotensin II infusion via subcutaneous osmotic… vs Vehicle or phenylephrine infusion via…
Design
Preclinical, Images were analyzed in a blinded manner
Follow-up
up to 28 days
Authors
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May impair neurovascular coupling before and after hypertension in models; leaves open translation to human cerebrovascular risk.
Does slow pressor angiotensin II infusion induce cerebrovascular dysfunction before the development of hypertension in mice?
Slow pressor doses of angiotensin II induce cerebrovascular dysfunction and oxidative stress that precede the development of hypertension and persist after blood pressure normalization.
Capone et al. (2010) studied this question.
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