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July 24, 2008AJP Renal PhysiologyOpen Access

Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease

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Why the study?

Does chromosome substitution from Brown Norway rats attenuate salt-sensitive hypertension and renal disease in Dahl SS/Mcwi rats on a high-salt diet?

Population

Male and female Dahl SS/Mcwi rats, Brown Norway rats, and 22 consomic strains

Comparison

High-salt diet for 3 weeks and substitution of… vs Parental Dahl SS/Mcwi and Brown Norway control…

Design

Preclinical

Follow-up

3 weeks

Authors

DMDavid L. MattsonAugusta UniversityMDMelinda R. DwinellMedical College of WisconsinAGAndrew S. GreeneAtrium Health Wake Forest Baptist

Discussion

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Implication

Chromosome substitutions identify hypertension loci in Dahl rats; leaves open specific gene discovery and human translation.

Structured PICO

Does chromosome substitution from Brown Norway rats attenuate salt-sensitive hypertension and renal disease in Dahl SS/Mcwi rats on a high-salt diet?

P
Population
Male and female Dahl SS/Mcwi (Dahl Salt-Sensitive) rats, Brown Norway (BN) rats, and 22 consomic strains (10-12 rats/group)
I
Intervention
High-salt (8.0% NaCl) diet for 3 weeks and substitution of individual chromosomes from the Brown Norway (BN) rat onto the Dahl SS/Mcwi genetic background
C
Comparator
Parental Dahl SS/Mcwi and Brown Norway (BN) control rats on the same high-salt diet
O
Outcome
Mean arterial blood pressure, urinary protein excretion, and albumin excretionsurrogate

Genes contributing to salt-sensitive hypertension and renal disease are located on multiple chromosomes in the Dahl SS/Mcwi rat, providing a stable genetic platform for further gene mapping.

Cite This Study

Mattson et al. (2008) studied this question.

synapsesocial.com/papers/6a6fafe6ac440176ef28586ehttps://doi.org/10.1152/ajprenal.90341.2008

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats2007 · 48 citations
  2. 2Brown Norway Chromosome 13 Confers Protection From High Salt to Consomic Dahl S Rat2001 · 195 citations
  3. 3Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat2007 · 73 citations
  4. 4Substitution of chromosome 1 ameliorates l -NAME hypertension and renal disease in the fawn-hooded hypertensive rat2005 · 32 citations
  5. 5Evidence of Gene—Gene Interactions in the Genetic Susceptibility to Renal Impairment after Unilateral Nephrectomy2000 · 74 citations