Why the study?
Does introgression of chromosome 13 from normotensive Brown Norway rats protect Dahl salt-sensitive rats from high salt-induced hypertension and renal damage?
Population
Dahl salt-sensitive rats, normotensive inbred Brown Norway rats, and consomic rats with chromosome 13 from…
Comparison
High salt (4% NaCl) diet for 4 weeks vs Between-strain comparison
Design
Preclinical
Follow-up
4 weeks
Authors
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Chromosome 13 introgression identifies protective loci in salt-sensitive models; leaves open human translation and requires prospective validation.
Does introgression of chromosome 13 from normotensive Brown Norway rats protect Dahl salt-sensitive rats from high salt-induced hypertension and renal damage?
Introgression of chromosome 13 from normotensive Brown Norway rats into Dahl salt-sensitive rats confers significant protection against high salt-induced hypertension and renal damage.
Cowley et al. (2001) studied this question.
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