Population
Dahl salt-sensitive SS/JrHsdMcwi rats and overlapping congenic lines covering chromosome 13 generated from…
Comparison
Substitution of chromosome 13 regions from the… vs Dahl salt-sensitive SS/JrHsdMcwi rat background
Design
Preclinical
Follow-up
2 weeks
Authors
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No immediate clinical implications for hypertension; leaves open epistatic gene mapping on chromosome 13 for translational validation.
Four discrete regions on rat chromosome 13 contain genes that interact epistatically to attenuate the development of salt-sensitive hypertension.
Moreno et al. (2007) studied this question.
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