Why the study?
Does the sex chromosome origin influence blood pressure and left ventricular weight in Lyon hypertensive rats?
Does the sex chromosome origin influence blood pressure and left ventricular weight in Lyon hypertensive rats?
In the Lyon rat model, relative left ventricular weight has a specific genetic determination partly contributed by a locus on the X chromosome, independent of blood pressure.
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X-linked locus may contribute to LV mass independent of BP in this rat model; hypothesis-generating for human LVH genetics and requires validation.
Vincent et al. (1996) studied this question.
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