A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.
Why the study?
Do genetic factors influence the acute blood pressure response to antihypertensive drugs in Lyon hypertensive rats?
Population
Backcross population (n = 281) derived from a cross of the Lyon hypertensive rat with Lyon normotensive rat
Design
Preclinical
Authors
Discussion
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Implication
Supports genetic modulation of antihypertensive response in rat models; leaves open translation to human pharmacogenomics.
Structured PICO
Do genetic factors influence the acute blood pressure response to antihypertensive drugs in Lyon hypertensive rats?
P
Population
Backcross population (n = 281) derived from a cross of the Lyon hypertensive rat with Lyon normotensive rat
I
Intervention
Acute administration of a dihydropyridine calcium antagonist (PY108-068), a ganglionic blocking agent (trimetaphan), or an angiotensin II subtype 1 receptor antagonist (losartan)
O
Outcome
Acute systolic and diastolic blood pressure responses to pharmacological modulationsurrogate
A specific genetic locus on rat chromosome 2 significantly influences the blood pressure response to a calcium channel blocker, supporting a genetic basis for heterogeneity in antihypertensive drug efficacy.
Cite This Study
Vincent et al. (1997) studied this question.