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April 1, 1995Journal of Clinical MicrobiologyOpen Access

Typing of human astroviruses from clinical isolates by enzyme immunoassay and nucleotide sequencing

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Population

64 astrovirus-positive specimens from nine collections from seven countries

Design

Other

Authors

JNJacqueline S. NoelTLT W LeeJKJ. B. Kurtz

Discussion

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Overview

TYPE-EIA aligns antigenic and phylogenetic astrovirus typing; leaves open routine epidemiological adoption pending larger validation studies.

Structured PICO

P
Population
64 astrovirus-positive specimens from nine collections from seven countries
I
Intervention
Typing enzyme immunoassay (TYPE-EIA) and reverse transcriptase PCR with nucleotide sequencing
O
Outcome
Antigenic types (serotypes) and phylogenetic groupings (genotypes)surrogate

TYPE-EIA provides antigenic groupings that are entirely consistent with phylogenetic genotypes, offering a reliable method for epidemiological studies of astrovirus.

Cite This Study

Noel et al. (1995) studied this question.

synapsesocial.com/papers/6a6fb07226770c2b8de01dechttps://doi.org/10.1128/jcm.33.4.797-801.1995
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of astrovirus serotype 1 RNA, identification of the viral RNA-dependent RNA polymerase motif, and expression of a viral structural protein1994 · 146 citations
  2. 2Subgenomic RNA sequence of human astrovirus supports classification of Astroviridae as a new family of RNA viruses1993 · 196 citations
  3. 3RNA sequence of astrovirus: distinctive genomic organization and a putative retrovirus-like ribosomal frameshifting signal that directs the viral replicase synthesis.1993 · 287 citations
  4. 4The human astrovirus RNA-dependent RNA polymerase coding region is expressed by ribosomal frameshifting1994 · 122 citations
  5. 5THE FREQUENCY OF ASTROVIRUS AS A CAUSE OF DIARRHEA IN BALTIMORE CHILDREN1992 · 48 citations