Genetic and Antigenic Diversity of Human Rotaviruses: Potential Impact on Vaccination Programs

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Population

Children worldwide at risk for rotavirus-induced gastroenteritis

Design

Review

Authors

Discussion

May necessitate enhanced post-vaccination rotavirus strain surveillance; leaves open whether antigenic drift will reduce long-term vaccine efficacy.

Population

Children worldwide at risk for rotavirus-induced gastroenteritis

Intervention

Rotavirus vaccines

Outcome

Diversity of rotavirus strains and mechanisms of wild-type rotavirus evolution (genetic drift and genetic reassortment)

Rotavirus vaccination programs may drive viral evolution through genetic drift and reassortment, potentially impacting long-term vaccine efficacy.

Carl D. Kirkwood (2010) studied this question.

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May necessitate enhanced post-vaccination rotavirus strain surveillance; leaves open whether antigenic drift will reduce long-term vaccine efficacy.