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September 1, 1984Journal of VirologyOpen Access

Nucleotide sequence of the gene encoding the serotype-specific antigen of human (Wa) rotavirus: comparison with the homologous genes from simian SA11 and UK bovine rotaviruses

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Population

Human (Wa) rotavirus genome segment 9, simian SA11, and UK bovine rotaviruses

Design

Preclinical

Authors

MRMichael RichardsonEzequiel Dias FoundationAIAikichi IwamotoJapan Agency for Medical Research and DevelopmentNINobuko IkegamiOsaka National Hospital

Discussion

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Implication

Suggests antigenic hotspots in rotavirus VP7; leaves open their role in cross-protection and vaccine design.

Structured PICO

P
Population
Human (Wa) rotavirus genome segment 9, simian SA11, and UK bovine rotaviruses
I
Intervention
Nucleotide sequencing and amino acid sequence comparison
O
Outcome
Amino acid differences and hydrophilicity profile

Identified specific clustered amino acid differences and potential antigenic determinants in the VP7 protein of human rotavirus compared to animal strains.

Cite This Study

Richardson et al. (1984) studied this question.

synapsesocial.com/papers/6a6fb294439bab0cabc2e171https://doi.org/10.1128/jvi.51.3.860-862.1984
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A new method for sequencing DNA.1977 · 8,026 citations
  2. 2Cloning and sequence of UK bovine rotavirus gene segment 7: marked sequence homology with simban rotavirus gene segment 81983 · 38 citations
  3. 3A general strategy for cloning double-stranded RNA: nucleotide sepuence of the Simian-11 rotavirus gene 81982 · 84 citations
  4. 4Molecular cloning of double-stranded RNA virus genomes.1983 · 72 citations
  5. 5Nucleotide sequence of the gene encoding the serotype-specific glycoprotein of UK bovine rotavirus1983 · 80 citations