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December 1, 2014Open Access

Association of single nucleotide polymorphisms in the lens epithelium-derived growth factor (LEDGF/p75) with HIV-1 infection outcomes in brazilian HIV-1+ individuals

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Authors

NMNúria Mallorquí‐BaguéAFAna B. FagundoSMSusana Jiménez Murcia

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Overview

Controlled animal study finds unchanged lower gastrointestinal histomorphology and mucus intensity in rats given Cyclamen graecum extract, indicating negligible intestinal impact at tested doses.

Key Points

  • To evaluate the effects of 10-week oral administration of Cyclamen graecum tuber ethanolic extracts on rat lower gastrointestinal histomorphology and mucus intensity.
  • Fifteen rats were divided into three groups of 5: saline control, 0.1 g/L aqueous Cyclamen graecum tuber ethanolic extract, and 0.3 g/L extract, all administered orally for 10 weeks.
  • Small and large intestine specimens were evaluated using Hematoxylin and Eosin, Periodic acid-Schiff, and Alcian Blue (pH 1.0 and pH 2.5) staining to assess general architecture alongside neutral, sulfated, and acidic mucosubstances.
  • Histomorphological architecture of the small and large intestines displayed no observable structural disruption or epithelial changes across both extract-treated groups compared to controls.
  • Staining intensities for neutral, acidic, and sulfated mucosubstances via Alcian Blue and Periodic acid-Schiff reactions showed no observable alterations between treated animals and controls.

Cite This Study

Mallorquí‐Bagué et al. (2014) studied this question.

synapsesocial.com/papers/6a6fb31a439bab0cabc2e1fbhttps://doi.org/10.1371/journal.pone
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