Why the study?
Does coronary reperfusion after cardioplegic arrest alter monocyte function and cytokine levels in patients undergoing cardiovascular surgery?
Population
13 patients undergoing cardiovascular surgery with cardiopulmonary bypass
Comparison
Coronary reperfusion after cardioplegic arrest vs Baseline (before cardioplegic arrest)
Design
Cohort
Follow-up
Immediate post-reperfusion
Authors
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Reperfusion may heighten infection risk via monocyte depression in cardiac surgery; leaves open need for targeted immunomodulation trials.
Does coronary reperfusion after cardioplegic arrest alter monocyte function and cytokine levels in patients undergoing cardiovascular surgery?
Coronary reperfusion after cardioplegic arrest induces an IL-10-mediated functional depression of monocytes, including their adhesive and migratory capacities, without causing monocyte activation.
Sbrana et al. (2005) studied this question.
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