August 1, 1984Circulation ResearchOpen Access

Calcium, sodium, and the calcium paradox.

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Population

Adult rat hearts undergoing calcium-free perfusion and calcium repletion

Comparison

Sodium loading, verapamil, or nifedipine vs Standard conditions without sodium loading or…

Design

Preclinical

Authors

WNW. G. NaylerCross-Cutting Cardiology SPS E PerryTulane University JEJ. S. ElzThe University of Melbourne

Discussion

Member takes

Implication

Hypothesis-generating for distinct calcium influx phases in isolated hearts; leaves open any clinical relevance or therapeutic targeting.

Structured PICO

Population

Adult rat hearts undergoing calcium-free perfusion and calcium repletion

Intervention

Sodium loading, verapamil (1 and 10 µmol/L), or nifedipine (1 µmol/L)

Comparator

Standard conditions without sodium loading or calcium channel blockers

Outcome

Gain in calcium and sodium, and loss of myoglobin during calcium repletionsurrogate

The early phase of calcium gain during the calcium paradox involves a verapamil/nifedipine-sensitive component, while the late phase is insensitive and likely involves sodium-calcium exchange.

Cite This Study

Nayler et al. (1984) studied this question.

synapsesocial.com/papers/6a6fb8c3f44fa9f079dd3225 https://doi.org/10.1161/01.res.55.2.227

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