October 1, 1988Molecular and Cellular BiologyOpen Access

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

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Population

HeLaM cells and GM2767 cells

Design

Preclinical

Authors

RTRaj K. TiwariDr. K.N.Modi University JKJyotirmoy KusariCity Of Hope National Medical Center RKRakesh KumarAISECT University

Discussion

Member takes

Implication

2-aminopurine inhibition implicates protein kinase activity in dsRNA/interferon signaling; leaves open in vivo validation and therapeutic relevance.

Structured PICO

Population

HeLaM cells and GM2767 cells

Intervention

10 mM 2-aminopurine

Outcome

Inhibition of mRNA induction by double-stranded RNA and interferonssurrogate

2-aminopurine selectively blocks the transcriptional induction of specific genes by double-stranded RNA and interferons, suggesting a role for protein kinase activity in these signaling pathways.

Limitations

No direct experimental evidence is available as yet for the hypothesis that protein kinase activity is necessary

Cite This Study

Tiwari et al. (1988) studied this question.

synapsesocial.com/papers/6a6fbb4226a7f98052dc566c https://doi.org/10.1128/mcb.8.10.4289

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Implication

2-aminopurine inhibition implicates protein kinase activity in dsRNA/interferon signaling; leaves open in vivo validation and therapeutic relevance.

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider