Population
Chick embryo cells and mouse L cells infected with viral inducers of interferon
Comparison
2-aminopurine (up to 10 mM) vs Control (no drug) or actinomycin D
Design
Preclinical
Authors
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2-aminopurine blocks early interferon induction; hypothesis-generating for dsRNA-dependent protein kinase role, requires human validation.
2-aminopurine selectively and reversibly blocks an early transcriptional stage of interferon induction, suggesting a role for dsRNA-dependent protein kinase as an induction receptor.
Marcus et al. (1988) studied this question.
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