Why the study?
Does 2-aminopurine block the transcriptional activation of cellular genes by virus, double-stranded RNA, and interferons in human cells?
Population
Human cell lines
Design
Preclinical
Authors
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Hypothesis-generating for antiviral gene regulation in animal models; leaves open translation to human cells or therapies.
Does 2-aminopurine block the transcriptional activation of cellular genes by virus, double-stranded RNA, and interferons in human cells?
2-aminopurine selectively blocks an early signal transduction step required for gene induction by viruses, double-stranded RNA, and interferons in human cells.
Wathelet et al. (1989) studied this question.
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