Clonal derivatives of the RD-114 cell line exhibit significant heterogeneity in their antiviral and gene-inducing responses to interferons, indicating that IFN treatment generates multiple signals leading to varied phenotypes.
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Heterogeneity in clonal IFN responses warrants caution generalizing antiviral effects; leaves open mechanisms of differential signaling for validation in primary models.
Kumar et al. (1987) studied this question.
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