August 1, 1999Arthritis & Rheumatism
DNA typing of maternal HLA in congenital complete heart block: Comparison with systemic lupus erythematosus and primary Sj�gren's syndrome
Why the study?
Which maternal HLA alleles or haplotypes are associated with isolated congenital complete heart block in offspring of anti-Ro-positive mothers?
Population
54 Italian anti-Ro-positive mothers, including 13 mothers of children with congenital complete heart block…
Design
Case-control
Authors
Discussion
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Implication
May aid risk stratification in anti-Ro-positive pregnancies; hypothesis-generating and requires prospective validation before guiding practice.
Structured PICO
Which maternal HLA alleles or haplotypes are associated with isolated congenital complete heart block in offspring of anti-Ro-positive mothers?
P
Population
54 Italian anti-Ro-positive mothers, including 13 mothers of children with congenital complete heart block (CCHB) and 41 mothers with healthy children (20 with systemic lupus erythematosus [SLE] and 21 with Sjögren's syndrome [SS]).
C
Comparator
Anti-Ro-positive mothers with healthy children (SLE or SS)
O
Outcome
Frequency of maternal HLA alleles or haplotypes associated with isolated congenital complete heart block (CCHB) in offspringsurrogate
Maternal HLA-DRB1*03011 combined with anti-52-kd SSA/Ro antibodies identifies the highest risk for congenital complete heart block in offspring.
Cite This Study
Colombo et al. (1999) studied this question.