Why the study?
Does a high preprocedural neutrophil to lymphocyte ratio predict stent thrombosis and in-hospital mortality in patients with STEMI?
Does a high preprocedural neutrophil to lymphocyte ratio predict stent thrombosis and in-hospital mortality in patients with STEMI?
A high preprocedural neutrophil to lymphocyte ratio is a significant predictor of stent thrombosis and in-hospital mortality in patients presenting with STEMI.
High preprocedural NLR was associated with stent thrombosis and mortality in STEMI; leaves open incremental value pending prospective validation.
We investigated whether the neutrophil to lymphocyte ratio (NLR) can predict stent thrombosis (STh) and high mortality rate in patients with ST-segment elevation myocardial infarction (STEMI). We analyzed data of 102 patients with STh and 450 patients with STEMI admitted to 2 high volume hospitals. Preprocedural NLR was significantly higher in patients with STh (P < .001). There was a significantly higher mortality rate in patients with high NLR during hospitalization (P < .001). Also, in the STh group there was a significantly higher mortality rate in patients with high NLR (P < .001). In receiver-operating characteristic analysis, NLR >4.8 had 56% sensitivity and 68% specificity for predicting STh. The NLR >4.9 had 70% sensitivity and 65% specificity for predicting in-hospital mortality. On multivariate regression analysis, NLR was found to be significantly related to STh. In patients with STEMI, preprocedural high NLR is associated with both STh and higher mortality rates.
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Ayça et al. (2014) studied this question.
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