Why the study?
Does olmesartan improve cerebral hemodynamics and rehabilitative outcomes in hypertensive patients with a history of stroke?
Does olmesartan improve cerebral hemodynamics and rehabilitative outcomes in hypertensive patients with a history of stroke?
In a small cohort of hypertensive patients with prior stroke, 8 weeks of olmesartan therapy improved cerebral hemodynamics and rehabilitative outcomes.
May support olmesartan for cerebral hemodynamics in post-stroke hypertension; hypothesis-generating, requires RCTs before practice change.
We aimed to determine the effects of angiotensin II receptor blocker on cerebral hemodynamics and rehabilitative outcome. Sixteen hypertensive patients with a history of stroke received 10-20 mg olmesartan daily for eight weeks. Blood pressure decreased after treatment compared with the baseline, whereas cerebral blood flow (CBF) values of the affected and nonaffected sides increased. The results of the cerebrovascular reserve capacity were also statistically increased in the affected side. Improvements were observed in three rehabilitative outcome parameters. These findings suggest that olmesartan has beneficial effects in hypertensive patients with stroke and impaired CBF autoregulation, and might improve cerebral circulation and rehabilitative outcome.
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Matsumoto et al. (2010) studied this question.
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