January 23, 2008AJP Regulatory Integrative and Comparative Physiology

Sympathetic nerve activity in the superior cervical ganglia increases in response to imposed increases in arterial pressure

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Population

Anesthetized and ventilated lambs (n=11)

Comparison

Imposed increases in arterial pressure and… vs Baseline arterial pressure

Design

Preclinical

Authors

PCPriscila A. CassagliaOregon Health & Science University RGRobert I. GriffithsBoston Scientific (United States)AWAdrian M. WalkerYale University

Discussion

Member takes

Implication

May inform neonatal cerebral autoregulation mechanisms; leaves open translation to human sympathetic responses.

Structured PICO

Population

Anesthetized and ventilated lambs (n=11)

Intervention

Imposed increases in arterial pressure (pharmacologically via adrenaline, phenylephrine, or ANG II, or mechanically via intravascular balloon) and decreases in arterial pressure (via sodium nitroprusside)

Comparator

Baseline arterial pressure

Outcome

Sympathetic nerve activity (SNA) recorded from the superior cervical ganglion (SCG)surrogate

Direct recording from the superior cervical ganglion in lambs demonstrates that sympathetic nerve activity increases during induced hypertension but not hypotension, supporting its protective role in cerebral circulation.

Cite This Study

Cassaglia et al. (2008) studied this question.

synapsesocial.com/papers/6a6fdcafac440176ef2883e4 https://doi.org/10.1152/ajpregu.00332.2007

Topics

Hypertension management

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Sympathetic nerve activity in the superior cervical ganglia increases in response to imposed increases in arterial pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Sympathetic nerve activity in the superior cervical ganglia increases in response to imposed increases in arterial pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider