January 1, 1989Journal of VirologyOpen Access

Effect of mutations and deletions in a bicistronic mRNA on the synthesis of influenza B virus NB and NA glycoproteins

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Population

Eucaryotic cells expressing recombinant DNA molecules derived from influenza B virus RNA segment 6

Comparison

Changes in the 5'-terminal region of the mRNA… vs Wild-type mRNA sequence with normal position of…

Design

Preclinical

Authors

MWMark A. WilliamsUniversity of Warwick RLRobert A. LambFlorida State University

Discussion

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Implication

May guide antiviral design targeting translation; leaves open in vivo validation in mammalian systems.

Structured PICO

Population

Eucaryotic cells expressing recombinant DNA molecules derived from influenza B virus RNA segment 6

Intervention

Changes in the 5'-terminal region of the mRNA, including deletions, insertions, and site-specific mutations

Comparator

Wild-type mRNA sequence with normal position of the first AUG codon

Outcome

Accumulation of NB and NA glycoproteinssurrogate

The study demonstrates that the position of the first AUG codon and an element in the 5' untranslated leader region are critical for regulating the synthesis of influenza B virus NB and NA glycoproteins from a bicistronic mRNA.

Cite This Study

Williams et al. (1989) studied this question.

synapsesocial.com/papers/6a6fe6d9660549caf2c470fb https://doi.org/10.1128/jvi.63.1.28-35.1989

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Effect of mutations and deletions in a bicistronic mRNA on the synthesis of influenza B virus NB and NA glycoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of mutations and deletions in a bicistronic mRNA on the synthesis of influenza B virus NB and NA glycoproteins

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider