March 26, 2014Circulation Arrhythmia and ElectrophysiologyOpen Access

Determination of the Longest Intrapatient Left Ventricular Electrical Delay May Predict Acute Hemodynamic Improvement in Patients After Cardiac Resynchronization Therapy

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Why the study?

Does pacing at the site of longest left ventricular electrical delay (Q-LV interval) improve acute hemodynamics (LV dP/dtmax) in patients undergoing cardiac resynchronization therapy?

Population

32 consecutive patients undergoing cardiac resynchronization therapy device implantation, mean age 71±11…

Comparison

Pacing at different sites in tributary veins of… vs Baseline and pacing at alternative sites.

Design

Cohort

Follow-up

Acute (during implantation)

Authors

FZFrancesco ZanonElectrophysiology EBEnrico BaraccaOspedale Santa Maria della Misericordia di Rovigo GPGianni PastoreOspedale Santa Maria della Misericordia di Rovigo

Discussion

Member takes

Implication

May guide LV lead placement to longest Q-LV sites for acute CRT response; hypothesis-generating pending randomized outcome trials.

Structured PICO

Does pacing at the site of longest left ventricular electrical delay (Q-LV interval) improve acute hemodynamics (LV dP/dtmax) in patients undergoing cardiac resynchronization therapy?

Population

32 consecutive patients undergoing cardiac resynchronization therapy device implantation, mean age 71±11 years, 23 men, mean LVEF 30±6%, 18 with ischemic cardiomyopathy, mean QRS 181±25 ms.

Intervention

Pacing at different sites in tributary veins of the coronary sinus to measure Q-LV interval (left ventricular electrical delay).

Comparator

Baseline (unpaced) and pacing at alternative sites.

Outcome

Acute hemodynamic improvement evaluated by invasive measurement of LV dP/dtmax.surrogate

Pacing the left ventricle at the site of longest electrical delay (Q-LV interval) during CRT implantation strongly predicts maximum acute hemodynamic improvement.

Cite This Study

Zanon et al. (2014) studied this question.

synapsesocial.com/papers/6a6fe7916c240de38cdb9e2f https://doi.org/10.1161/circep.113.000850

Topics

Cardiac device therapy HFrEF treatment Heart failure

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Determination of the Longest Intrapatient Left Ventricular Electrical Delay May Predict Acute Hemodynamic Improvement in Patients After Cardiac Resynchronization Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Determination of the Longest Intrapatient Left Ventricular Electrical Delay May Predict Acute Hemodynamic Improvement in Patients After Cardiac Resynchronization Therapy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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