July 22, 2019Pediatric DiabetesOpen Access

Increased body fat and reduced insulin sensitivity are associated with impaired endothelial function and subendocardial viability in healthy, non‐Hispanic white adolescents

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Why the study?

Cardiovascular disease originates in adolescence, and the study aimed to evaluate how early markers of cardiovascular risk relate to physical, inflammatory, and metabolic markers in healthy adolescents.

Population

75 healthy non-Hispanic, white adolescents

Comparison

Relationships between vascular/cardiac functional markers and physical, inflammatory, and metabolic measures

Authors

RHRobert P. HoffmanZhejiang Chinese Medical University MCMelanie M. CopenhaverNationwide Children's Hospital DZDanlei ZhouNationwide Children's Hospital

Discussion

Member takes

Implication

Associations of early CV markers with metabolic factors in adolescents are hypothesis-generating; leaves open links to adult outcomes.

Structured PICO

Population

75 healthy non-Hispanic white adolescents, mean age 15.0 ± 1.7 years, 34 female, mean BMI 22.0 ± 5.8 kg/m2.

Outcome

Relationships of endothelial dysfunction (reactive hyperemia), arterial stiffness (augmentation index AIx75), and endocardial oxygen supply:demand ratios (Buckberg subendocardial viability ratio) to physical, inflammatory, and metabolic markers.surrogate

Increased fat mass and decreased insulin sensitivity are associated with early markers of cardiovascular risk, such as poorer vascular function, in healthy adolescents.

Cite This Study

Hoffman et al. (2019) studied this question.

synapsesocial.com/papers/6a6fe84ef44fa9f079dd66fc https://doi.org/10.1111/pedi.12896

Topics

Women and heart disease

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Increased body fat and reduced insulin sensitivity are associated with impaired endothelial function and subendocardial viability in healthy, non‐Hispanic white adolescents

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Increased body fat and reduced insulin sensitivity are associated with impaired endothelial function and subendocardial viability in healthy, non‐Hispanic white adolescents

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider