Key result
Lower syndecan-1, lower PlGF, and elevated UACR are linked to superimposed preeclampsia in chronic hypertension.
Cohort (n=90)
Prospective cohort study assesses maternal and placental factors linked to superimposed preeclampsia in women with chronic hypertension, suggesting pathophysiological insights.
OBJECTIVE: To assess the contribution of maternal and placental factors to the development of superimposed preeclampsia in women with chronic hypertension. METHODS: Endothelial and renal function markers were serially assessed in 90 pregnant women with chronic hypertension and controls. RESULTS: weeks in women with chronic hypertension who subsequently developed superimposed preeclampsia compared with those who did not. Decreased PlGF and raised urine albumin:creatinine ratio were also associated with development of superimposed preeclampsia. CONCLUSION: Decreased syndecan-1 and PlGF concentrations implicate endothelial glycocalyx disturbance and reduced placental angiogenic capacity, respectively, in the pathophysiology of superimposed preeclampsia.
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Bramham et al. (2020) conducted a cohort in Chronic hypertension in pregnancy (n=90). Maternal and placental factors (syndecan-1, PlGF, urine albumin:creatinine ratio) vs. Women with chronic hypertension who did not develop superimposed preeclampsia was evaluated on Development of superimposed preeclampsia. Decreased syndecan-1, decreased PlGF concentrations, and raised urine albumin:creatinine ratio were associated with the development of superimposed preeclampsia in women with chronic hypertension.
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