Population
A-10 and aortic vascular smooth muscle cells (VSMC)
Comparison
Peroxynitrite treatment for 24 h vs Control
Design
Preclinical
Follow-up
24 h
Authors
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Peroxynitrite may impair VSMC signaling; leaves open its role in human vascular disease and need for in vivo confirmation.
Peroxynitrite decreases G(i) protein expression and adenylyl cyclase signaling in vascular smooth muscle cells via a cGMP-independent mechanism.
Bassil et al. (2007) studied this question.
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