Cardiac MR elastography correlates strongly with invasive left ventricular pressure in a porcine model, suggesting its potential as a noninvasive tool for assessing pressure-volume function.
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Supports MRE for noninvasive LV pressure assessment in animals; leaves open human validation before clinical use.
PURPOSE OF STUDY: To compare magnetic resonance elastography (MRE) with ventricular pressure changes in an animal model. METHODS: Three pigs of different cardiac physiology (weight, 25 to 53 kg; heart rate, 61 to 93 bpm; left ventricular [LV] end-diastolic volume, 35 to 70 ml) were subjected to invasive LV pressure measurement by catheter and noninvasive cardiac MRE. Cardiac MRE was performed in a short-axis view of the heart and applying a 48.3-Hz shear-wave stimulus. Relative changes in LV-shear wave amplitudes during the cardiac cycle were analyzed. Correlation coefficients between wave amplitudes and LV pressure as well as between wave amplitudes and LV diameter were determined. RESULTS: A relationship between MRE and LV pressure was observed in all three animals (R2 >or= 0.76). No correlation was observed between MRE and LV diameter (R2 <or= 0.15). Instead, shear wave amplitudes decreased 102 +/- 58 ms earlier than LV diameters at systole and amplitudes increased 175 +/- 40 ms before LV dilatation at diastole. Amplitude ratios between diastole and systole ranged from 2.0 to 2.8, corresponding to LV pressure differences of 60 to 73 mmHg. CONCLUSION: Externally induced shear waves provide information reflecting intraventricular pressure changes which, if substantiated in further experiments, has potential to make cardiac MRE a unique noninvasive imaging modality for measuring pressure-volume function of the heart.
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Elgeti et al. (2009) studied this question.
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