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MRE tracks LV filling pressure in pigs; leaves open validation for noninvasive clinical assessment.
PURPOSE: To compare magnetic resonance elastography (MRE) effective stiffness to end-diastolic pressure at different loading conditions to demonstrate a relationship between myocardial MRE effective stiffness and end-diastolic left ventricular (LV) pressure. MATERIALS AND METHODS: MRE was performed on four pigs to measure the end-diastolic effective stiffness under different loading conditions. End-diastolic pressure was increased by infusing Dextran-40 (20% of blood volume). For each infusion of Dextran-40, end-diastolic pressure was recorded and end-diastolic effective stiffness was measured using MRE. In each pig, least-square linear regression was performed to determine the correlation between end-diastolic effective stiffness and end-diastolic LV pressure. RESULTS: A linear correlation was found between end-diastolic LV pressure and end-diastolic effective stiffness with R(2) ranging from 0.73-0.9. A linear correlation with R(2) = 0.26 was found between end-diastolic LV pressure and end-diastolic effective stiffness when pooling data points from all pigs. CONCLUSION: End-diastolic effective myocardial stiffness increases linearly with end-diastolic LV pressure.
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Kolipaka et al. (2011) studied this question.
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