The isovolumic relaxation period of the left ventricle is best modeled as an exponential decay with a variable asymptote using the Levenburg-Marquardt algorithm.
May enhance LV diastolic quantification; leaves open outcome validation before clinical adoption.
The isovolumic relaxation period of the left ventricular pressure curve in man has been assumed to be best represented by an exponential decay. To determine which model most closely approximates the empiric pressure data of isovolumic relaxation in man, several models were compared. They included linear, exponential with a zero mmHg pressure asymptote, exponential with a variable asymptote, and second-to fifth-order polynomials. In addition, four different methods of computing parameters of isovolumic relaxation by the exponential model with a variable asymptote were tested. It was found that the isovolumic relaxation period approximates an exponential, that the theoretic asymptote is variable, and that the Levenburg-Marquardt algorithm can be used efficiently to model this period.
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Bernardi et al. (1985) studied this question.
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