February 14, 2008Genome biologyOpen Access

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes

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Population

Neonatal rat cardiomyocytes

Design

Preclinical

Follow-up

4 hours

Authors

TCTimothy E. CullingfordImperial College London TMThomais MarkouAstraZeneca (Australia)SFStephen J. FullerNepean Hospital

Discussion

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Implication

These ERK-dependent transcriptional changes in cardiomyocytes are hypothesis-generating for hypertrophy mechanisms; should not yet inform clinical practice.

Structured PICO

Population

Neonatal rat cardiomyocytes

Intervention

Endothelin-1 over 4 h (with cycloheximide or U0126 to differentiate pathways)

Outcome

Early transcriptional responses (immediate early gene and second phase RNAs)surrogate

Endothelin-1 induces phasic transcriptional responses in cardiomyocytes largely mediated by ERK1/2 signaling, providing insight into the molecular mechanisms of cardiac hypertrophy.

Cite This Study

Cullingford et al. (2008) studied this question.

synapsesocial.com/papers/6a6ff6a66ceb2bbd16dfc36b https://doi.org/10.1186/gb-2008-9-2-r32

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Implication

These ERK-dependent transcriptional changes in cardiomyocytes are hypothesis-generating for hypertrophy mechanisms; should not yet inform clinical practice.

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider