Identification of a Sudden Cardiac Death Susceptibility Locus at 2q24.2 through Genome-Wide Association in European Ancestry Individuals
Why the study?
Does the BAZ2B locus or interval-prolonging alleles increase the risk of sudden cardiac death in individuals of European ancestry?
Population
1,283 sudden cardiac death cases and >20,000 control individuals of European ancestry from 5 studies, with…
Comparison
Presence of the BAZ2B locus risk allele at… vs Absence of the risk alleles (control individuals)
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
May inform SCD risk models in Europeans; extends genetic associations from repolarization traits to sudden death.
Structured PICO
Does the BAZ2B locus or interval-prolonging alleles increase the risk of sudden cardiac death in individuals of European ancestry?
P
Population
1,283 sudden cardiac death (SCD) cases and >20,000 control individuals of European ancestry from 5 studies (initial meta-analysis), with follow-up genotyping in up to 3,119 SCD cases and 11,146 controls from 11 European ancestry studies.
I
Intervention
Presence of the BAZ2B locus risk allele at 2q24.2 and 49 SNPs modulating electrocardiographic traits (QRS, QT, and RR intervals)
C
Comparator
Absence of the risk alleles (control individuals)
O
Outcome
Sudden cardiac death (SCD)hard clinical
The BAZ2B locus at 2q24.2 and aggregate interval-prolonging alleles are significantly associated with an increased risk of sudden cardiac death in individuals of European ancestry.
Cite This Study
Arking et al. (2011) studied this question.