Population
Sarcoplasmic reticulum membranes
Comparison
Nonsolubilizing concentrations of C12E8 vs Normal (unperturbed) conditions
Design
Preclinical
Authors
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Preclinical detergent effects on SERCA kinetics should not alter practice; extends understanding of ATPase cycle rate-limiting transitions.
Detergent perturbation of sarcoplasmic reticulum membranes reveals that the Ca2E1P to E2P transition is typically rate-limiting for the ATPase cycle, while dephosphorylation becomes rate-limiting under specific conditions.
Champeil et al. (1986) studied this question.
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