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July 22, 2014Frontiers in EndocrinologyOpen Access

Down-regulation of TLR4 protein content was observed in rat cardiac myocytes and equine myocardium following exposure to supraphysiologic insulin concentrations, with cardiac TLR4 expression negatively correlated with serum insulin concentration.

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Why the study?

Does supraphysiological insulin alter the expression of TLR4, markers of TLR4 signaling, and glucose transporters in the mammalian heart?

Population

Isolated rat cardiac myocytes and equine ventricular myocardium

Design

Preclinical

Authors

MLMelody A. de LaatKGKaylynn J. GruntmeirCPChristopher C. Pollitt

Discussion

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Overview

Insulin-mediated cardiac TLR4 modulation merits human validation; leaves open relevance to diabetic cardiomyopathy progression.

Structured PICO

Does supraphysiological insulin alter the expression of TLR4, markers of TLR4 signaling, and glucose transporters in the mammalian heart?

P
Population
Isolated rat cardiac myocytes and equine ventricular myocardium
I
Intervention
Supraphysiological insulin concentrations (in vitro incubation and in vivo prolonged, euglycemic, hyperinsulinemic clamp)
O
Outcome
TLR4 protein expressionsurrogate

Insulin infusion exerts an anti-inflammatory effect in the heart by down-regulating TLR4 expression, which may have implications for understanding and managing diabetic cardiomyopathy.

Cite This Study

Laat et al. (2014) studied this question.

synapsesocial.com/papers/6a70044a3ce530166bc2b746https://doi.org/10.3389/fendo.2014.00120
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Also Consider

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  1. 1TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes2012 · 98 citations
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  3. 3Systemic Delivery of siRNA Specific for Silencing TLR4 Gene Expression Reduces Diabetic Cardiomyopathy in a Mouse Model of Streptozotocin-Induced Type 1 Diabetes2020 · 23 citations
  4. 4Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model*2009 · 16 citations
  5. 5TLR4 links innate immunity and fatty acid–induced insulin resistance2006 · 3,660 citations